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KMID : 0545120180280081391
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Journal of Microbiology and Biotechnology
2018 Volume.28 No. 8 p.1391 ~ p.1400
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Suppressive Effect of Fermented Angelica tenuissima Root Extract against Photoaging: Possible Involvement of Hemeoxygenase-1
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Park Yun-A
Lee Sung-Ryul
Lee Jin-Woo
Koo Hyun-Jung
Jang Seon-A
Yun Seung-Won
Kim Hyun-Ju
Woo Jeong-Suk
Park Myung-Rye
Kang Se-Chan
Kim Youn-Kyu
Sohn Eun-Hwa
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Abstract
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Angelica tenuissima root has historically been used as a traditional medicine in Korea. Previous studies have identified the anti-melanogenic effects of the extract of A. tenuissima root fermented by Aspergillus oryzae (FAT). This study investigated the protective effects of FAT against ultraviolet light B exposure (UVB; 30 mJ/cm2) in HaCaT (human keratinocyte) or Hs68 (human foreskin fibroblast) skin cells. FAT treatment was able to stimulate wound healing rate at the basal condition. FAT also favored the maintenance and/or improvement of extracellular matrix impairment caused by UVB irradiation through: 1) upregulation of procollagen Type-1 synthesis and secretion; 2) suppression of MMP-1 and elastase expression. FAT was able to play a role in the attenuation of inflammatory responses caused by UVB irradiation via upregulation of photo-protective hemeoxygease-1 and suppression of proinflammatory cyclooxygenase-2 expression. After further verification of the anti-photoaging potential of FAT, it could be utilized as an effective ingredient in anti-aging and anti-wrinkle cosmetics.
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KEYWORD
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Angelica tenuissima, photoaging, fermentation, ultraviolet light B, hemeoxygenase-1, extracellular matrix
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